Pearl Biosystem (PBioS) is a CRO that brings a disruptive 3D screening solutions that help pharmaceutical, cosmetics, and chemical companies to accelerate safety and efficacy testing, and bring better drugs or ingredients to the market in a safer, faster, more efficient, and animal-free way.

PbioS technology based on synthetic pearls to accelerate your molecule (chemical, biosimilar, extract…) selection process.

PBioS is a new molecule validation process to accelerate market access and reduce your market access cost.
Our process applies to the Research department of our customers, at the preclinical stage (before or after an animal model), to choose the most relevant molecules before carrying out the tests into some long clinical trials.

What does Pearl BioSystem solve ?

Current 3D cell culture used gels (Matrigel), preotic network, or microfluidic.

Those technologies offer conditions too restricted in terms of diffusion of the tested molecules, manipulation at low temperature, and recovery of intact tumoroids.

Our 3D culture technology based on liquid pearls loaded with human cell lines makes it possible to recreate conditions closest to in vivo nude mouse models.

The originality of our liquid pearl cultures comes precisely from the fact that the only extracellular matrix that binds our human cell lines together is the one that the cells secrete themselves. No artificial matrix is added (animal origin, batch problems).

Our specific human cell-line “organoids” obtained from various cellular phenotypes are in liquid suspension, allowing rapid diffusion of any molecule added to the pearl, whether hydrophilic, lipid-soluble or of a protein nature (e.g., antibodies, nanostructures).

The added molecules are therefore sure to encounter cells from all sides and will not be hindered or adsorbed by gels or colloids.

Aligned with FDA to reduce Animal Testing : Congress Approves Landmark

FDA Modernization Act promises to spare animals, bring safer and better treatments to patients, and drive down drug prices

December 23, 2022 18:48 ET | Source: Animal Wellness Action

Would you like to improve the selection of your promising molecules using a fast, secure and reliable test before embarking on a costly in vivo phase with sometimes uncertain results?

Please click on our general video intro that summarizes our technology and multiple offers in both pharma and cosmetic markets.

Did you know that there is a system similar to in vivo: the “ in Perlo™ ” test based on the use of new biopearls?

Imagine reducing the number of your cohort of 'nude' mice or humanized mice or any other animal (monkey – pig – dog…) by a batch of synthetic pearl?

Pearl BioSystem is a pioneering company that has developed an original and very effective 3D culture test (the in perlo™ model” for synthetic and/or natural compound tests, as well as validation tests.

We position PBioS between the in vitro and in vivo phases.

Over the past 10 years, Pearl BioSystem (PBioS) developed a very innovative,  rapid and accurate method for screening chemical libraries in liquid pearls, an animal-free model equivalent to xenograft experiments in nude mice but also compatible with other animal cell lines.
Our technology (CNRS patented) makes it possible to quickly confirm molecules potentially identified as promising, and to validate them for you in complete operational safety, without any animal affected and with a high level of confidentiality (only 1 mg of your molecules is required for an “ in PerloTM ” evaluation).
This new approach allows serene decision-making when testing the safety and efficacy of your synthetic molecules (biomimetics and peptides) or your molecules such as DNA, RNA, Ab or your natural extracts in development.

Thanks to its validated technology, PBioS can develop a tailor-made test on a weekly basis to evaluate and/or compare specific candidate molecules with

and could thus guarantee you considerable competitive advantages during your preclinical research phases.

PBioS was created to offer you a simple, fast and reliable tool to help you select your most promising molecules:

In either case, PBioS can save you a long and costly animal phase with sometimes uncertain results or select the best ingredients before going to the human clinical trials.

Our technology works for a variety of industry applications such as: