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Pearl Biosystem has developed a method to screen chemical libraries in liquid pearls by cultivating spheroids in a close to zero gravity environment.
In a recent review by Dr. Daan W. A. van den Nieuwenhof and colleagues, (https://www.nature.com/articles/s41526-024-00442-z), the authors focus on spheroid formation in microgravity (µG) and the implications for biomedical research cell culture. The paper aims to summarize existing research on these mechanisms.
In conclusion, this review highlights the synergy between tissue engineering and microgravity, showcasing its potential for innovations in spheroid and organoid production, tissue fabrication, and pharmaceutical and space-related research. While microgravity offers a unique environment for cellular self-assembly, challenges such as platform optimization, tissue acclimatization, and cellular heterogeneity must be addressed to advance reliable and reproducible techniques in this emerging field, a challenge we meet at Pearl Biosystem.